IP3 Receptor (phospho-Ser1756) rabbit pAb

  • Catalog No.:YP1364
  • Applications:WB
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • ITPR1 INSP3R1
    • Protein Name:
    • IP3 Receptor (Ser1756)
    • Human Gene Id:
    • 3708
    • Human Swiss Prot No:
    • Q14643
    • Mouse Swiss Prot No:
    • P11881
    • Immunogen:
    • Synthesized phosho peptide around human IP3 Receptor (Ser1756)
    • Specificity:
    • This antibody detects endogenous levels of Human Mouse Rat IP3 Receptor (phospho-Ser1756)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • WB 1:1000-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
    • Observed Band(KD):
    • 320
    • Background:
    • inositol 1,4,5-trisphosphate receptor type 1(ITPR1) Homo sapiens This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],
    • Function:
    • alternative products:There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.,domain:The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has
    • Subcellular Location:
    • nuclear inner membrane,nucleolus,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,calcineurin complex,postsynaptic density,membrane,integral component of membrane,sarcoplasmic reticulum,platelet
    • Expression:
    • Brain,Epithelium,Liver,Myeloid,T-cell,Uterus,