HNF1α (Phospho Ser247) rabbit pAb
- Catalog No.:YP1354
- Applications:WB
- Reactivity:Human;Rat;Mouse;
- Target:
- HNF1A
- Fields:
- >>Maturity onset diabetes of the young
- Gene Name:
- HNF1A TCF1
- Protein Name:
- HNF1α (Ser247)
- Human Gene Id:
- 6927
- Human Swiss Prot No:
- P20823
- Mouse Gene Id:
- 21405
- Mouse Swiss Prot No:
- P22361
- Rat Gene Id:
- 24817
- Rat Swiss Prot No:
- P15257
- Immunogen:
- Synthesized phosho peptide around human HNF1α (Ser247)
- Specificity:
- This antibody detects endogenous levels of Human HNF1α (phospho-Ser247)
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000
- Purification:
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
- Observed Band(KD):
- 69kD
- Background:
- The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
- Function:
- disease:Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].,disease:Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,disease:Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas.,function:Required
- Subcellular Location:
- Nucleus .
- Expression:
- Liver.
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