• Target：
• cGKII

• Fields：
• >>cGMP-PKG signaling pathway;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Thermogenesis;>>Long-term depression;>>Olfactory transduction;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Salivary secretion

• Gene Name：
• PRKG2

• Protein Name：
• cGMP-dependent protein kinase 2

• Human Gene Id：
• 5593

• Human Swiss Prot No：
• Q13237

• Mouse Swiss Prot No：
• Q61410

• Rat Gene Id：
• 25523

• Rat Swiss Prot No：
• Q64595

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PKG2 around the phosphorylation site of Ser126. AA range:92-141

• Specificity：
• Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PRKG2;PRKGR2;cGMP-dependent protein kinase 2;cGK 2;cGK2;cGMP-dependent protein kinase II;cGKII

• Molecular Weight(Da)：
• 87kD

• Background：
• This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,

• Subcellular Location：
• Apical cell membrane ; Lipid-anchor .

• Expression：
• Highly concentrated in brain, lung and intestinal mucosa.

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