p47-phox (phospho Ser328) Polyclonal Antibody

    • Catalog No.:YP1018
    • Applications:IHC-p,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • NCF1
      • Protein Name:
      • Neutrophil cytosol factor 1
      • Human Swiss Prot No:
      • P14598
      • Mouse Swiss Prot No:
      • Q09014
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human Neutrophil Cytosol Factor 1 around the phosphorylation site of Ser328. AA range:301-350
      • Specificity:
      • Phospho-p47-phox (S328) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S328.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • NCF1; NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox org
      • MolecularWeight(Da):
      • 44683
      • Background:
      • neutrophil cytosolic factor 1(NCF1) Homo sapiens The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,
      • Subcellular Location:
      • cytoplasm,rough endoplasmic reticulum,Golgi apparatus,cytosol,extrinsic component of membrane,dendrite,phagolysosome,NADPH oxidase complex,neuronal cell body,
      • Expression:
      • Lymph,Ovary,Spleen,Synovium,Umbilical vein,
      • Products Images
      • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Neutrophil Cytosol Factor 1 (Phospho-Ser328) Antibody
      • Immunohistochemistry analysis of paraffin-embedded human tonsil, using Neutrophil Cytosol Factor 1 (Phospho-Ser328) Antibody. The picture on the right is blocked with the phospho peptide.