• Target：
• IL-1RI

• Fields：
• >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>Th17 cell differentiation;>>Inflammatory mediator regulation of TRP channels;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Amoebiasis;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Fluid shear stress and atherosclerosis

• Gene Name：
• IL1R1

• Protein Name：
• Interleukin-1 receptor type 1

• Human Gene Id：
• 3554

• Human Swiss Prot No：
• P14778

• Mouse Gene Id：
• 16177

• Mouse Swiss Prot No：
• P13504

• Rat Swiss Prot No：
• Q02955

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496. AA range:471-520

• Specificity：
• Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL1R1;IL1R;IL1RA;IL1RT1;Interleukin-1 receptor type 1;IL-1R-1;IL-1RT-1;IL-1RT1;CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha;Interleukin-1 receptor type I;p80;CD antigen CD121a

• Observed Band(KD)：
• 65kD

• Background：
• This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],

• Function：
• function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,

• Subcellular Location：
• Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .

• Expression：
• Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.

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