• Target：
• CRMP-2

• Fields：
• >>Axon guidance

• Gene Name：
• DPYSL2

• Protein Name：
• Dihydropyrimidinase-related protein 2

• Human Gene Id：
• 1808

• Human Swiss Prot No：
• Q16555

• Mouse Gene Id：
• 12934

• Mouse Swiss Prot No：
• O08553

• Rat Gene Id：
• 25416

• Rat Swiss Prot No：
• P47942

• Immunogen：
• Synthesized phospho-peptide around the phosphorylation site of human CRMP-2 (phospho Ser522)

• Specificity：
• Phospho-CRMP-2 (S522) Polyclonal Antibody detects endogenous levels of CRMP-2 protein only when phosphorylated at S522.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DPYSL2;CRMP2;ULIP2;Dihydropyrimidinase-related protein 2;DRP-2;Collapsin response mediator protein 2;CRMP-2;N2A3;Unc-33-like phosphoprotein 2;ULIP-2

• Observed Band(KD)：
• 62kD

• Background：
• This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],

• Function：
• function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Membrane . Tightly but non-covalently associated with membranes.

• Expression：
• Ubiquitous.

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