• Target：
• ARPC4

• Gene Name：
• ARPC4 ARC20

• Protein Name：
• Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)

• Human Gene Id：
• 10093

• Human Swiss Prot No：
• P59998

• Mouse Gene Id：
• 68089

• Mouse Swiss Prot No：
• P59999

• Immunogen：
• Synthesized peptide derived from human ARPC4

• Specificity：
• This antibody detects endogenous levels of ARPC4 at Human, Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 18kD

• Function：
• Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .

• Subcellular Location：
• Cytoplasm, cytoskeleton . Cell projection . Nucleus .

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