• Target：
• CCM2

• Gene Name：
• CCM2 C7orf22 PP10187

• Protein Name：
• Malcavernin (Cerebral cavernous malformations 2 protein)

• Human Gene Id：
• 83605

• Human Swiss Prot No：
• Q9BSQ5

• Mouse Gene Id：
• 216527

• Mouse Swiss Prot No：
• Q8K2Y9

• Immunogen：
• Synthesized peptide derived from human CCM2

• Specificity：
• This antibody detects endogenous levels of CCM2 at Human, Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 49kD

• Function：
• Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).

• Subcellular Location：
• Cytoplasm .

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