FBL rabbit pAb

  • Catalog No.：YN5902
  • Applications：WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • FBL
    • Gene Name：
    • FBL FIB1 FLRN
    • Protein Name：
    • rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen)
    • Human Gene Id：
    • 2091
    • Human Swiss Prot No：
    • P22087
    • Mouse Swiss Prot No：
    • P35550
    • Immunogen：
    • Synthesized peptide derived from human FBL
    • Specificity：
    • This antibody detects endogenous levels of FBL at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Molecular Weight(Da)：
    • 35kD
    • Function：
    • S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .
    • Subcellular Location：
    • Nucleus, nucleolus . Nucleus, nucleoplasm . Fibrillar region of the nucleolus.

    Attributes

    • Code：
    • YN5902
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-12-23
    Order

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