FUS/TLS rabbit pAb

  • Catalog No.：YN5727
  • Applications：WB
  • Reactivity：Human;Mouse
    • Target：
    • FUS
    • Gene Name：
    • FUS TLS
    • Protein Name：
    • RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
    • Human Gene Id：
    • 2521
    • Human Swiss Prot No：
    • P35637
    • Mouse Swiss Prot No：
    • P56959
    • Immunogen：
    • Synthesized peptide derived from human FUS/TLS
    • Specificity：
    • This antibody detects endogenous levels of FUS/TLS at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Molecular Weight(Da)：
    • 58kD
    • Function：
    • DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response . Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing . Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay . Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair . In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
    • Subcellular Location：
    • Nucleus . Displays a punctate pattern inside the nucleus and is excluded from nucleoli. .
    • Expression：
    • Ubiquitous.

    Attributes

    • Code：
    • YN5727
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-12-22
    Order

    Related Products