• Target：
• CACNB3

• Fields：
• >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• Gene Name：
• CACNB3

• Protein Name：
• Voltage-dependent L-type calcium channel subunit beta-3

• Human Gene Id：
• 784

• Human Swiss Prot No：
• P54284

• Mouse Swiss Prot No：
• P54285

• Rat Swiss Prot No：
• P54287

• Immunogen：
• Synthetic Peptide of CACNB3

• Specificity：
• The antibody detects endogenous CACNB3 protein.

• Formulation：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-1000 IHC 1:200-500. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CACNB3;CACNLB3;Voltage-dependent L-type calcium channel subunit beta-3;CAB3;Calcium channel voltage-dependent subunit beta 3

• Observed Band(KD)：
• 50kD

• Background：
• This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011],

• Function：
• function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4.,tissue specificity:Expressed mostly in brain, smooth muscle and ovary.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Expressed mostly in brain, colon and ovary.

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