• Target：
• Cav3.3

• Fields：
• >>MAPK signaling pathway;>>Calcium signaling pathway;>>Circadian entrainment;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>GnRH secretion;>>Cushing syndrome

• Gene Name：
• CACNA1I

• Protein Name：
• Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3)

• Human Gene Id：
• 8911

• Human Swiss Prot No：
• Q9P0X4

• Rat Swiss Prot No：
• Q9Z0Y8

• Immunogen：
• Synthetic Peptide of Cav3.3 AA range: 210-290

• Specificity：
• Cav3.3 protein(A209) detects endogenous levels of Cav3.3

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100-200. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3;Ca(v)3.3)

• Observed Band(KD)：
• 240kD

• Background：
• calcium voltage-gated channel subunit alpha1 I(CACNA1I) Homo sapiens This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],

• Function：
• domain:Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent

• Subcellular Location：
• Membrane; Multi-pass membrane protein.

• Expression：
• Brain specific.

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