• Target：
• CNTF

• Fields：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway

• Gene Name：
• CNTF

• Protein Name：
• Ciliary neurotrophic factor (CNTF)

• Human Gene Id：
• 1270

• Human Swiss Prot No：
• P26441

• Mouse Swiss Prot No：
• P51642

• Rat Swiss Prot No：
• P20294

• Immunogen：
• Synthetic Peptide of CNTF

• Specificity：
• CNTF protein(A218) detects endogenous levels of CNTF

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-1000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CNTF;Ciliary neurotrophic factor;CNTF

• Observed Band(KD)：
• 30kD

• Background：
• The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010],

• Function：
• disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Nervous system.

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