GABA A Receptor α4 Polyclonal Antibody
- Catalog No.:YN5593
- Applications:WB;IHC;IF
- Reactivity:Human;Rat;Mouse
- Target:
- GABA A Receptor α4
- Fields:
- >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction
- Gene Name:
- GABRA4
- Protein Name:
- Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)
- Human Gene Id:
- 2557
- Human Swiss Prot No:
- P48169
- Mouse Swiss Prot No:
- Q9D6F4
- Rat Swiss Prot No:
- P28471
- Immunogen:
- Synthetic Peptide of GABA A Receptor α4 AA range: 149-199
- Specificity:
- GABA A Receptor α4 protein(A226) detects endogenous levels of GABA A Receptor α4
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- GABRA4;Gamma-aminobutyric acid receptor subunit alpha-4;GABA(A) receptor subunit alpha-4
- Observed Band(KD):
- 62kD
- Background:
- Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],
- Function:
- function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
- Expression:
- Brain,Brain cortex,
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- Antibody-FAQs
- Products Images
- Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with GABA A Receptor α4 Rabbit pAb diluted at 1:2,000.
- Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.
- Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using GABA A Receptor α4 Rabbit pAb diluted at 1:200.