• Target：
• NRG4

• Fields：
• >>ErbB signaling pathway;>>Amyotrophic lateral sclerosis

• Gene Name：
• NRG4

• Protein Name：
• Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]

• Human Gene Id：
• 145957

• Human Swiss Prot No：
• Q8WWG1

• Mouse Swiss Prot No：
• Q9WTX4

• Immunogen：
• Synthesized peptide derived from human protein . at AA range: 11-60

• Specificity：
• NRG4 Polyclonal Antibody detects endogenous levels of protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Observed Band(KD)：
• 12kD

• Background：
• The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008],

• Function：
• domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,subcellular location:Does not seem to be active.,

• Subcellular Location：
• [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-4]: Secreted .

• Expression：
• Breast,Liver,Prostate,

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