HBEGF Polyclonal Antibody

    • Catalog No.：YN2310
    • Applications：WB;ELISA
    • Reactivity：Human;Rat;Mouse
      • Target：
      • HBEGF
      • Fields：
      • >>Endocrine resistance;>>ErbB signaling pathway;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Epithelial cell signaling in Helicobacter pylori infection;>>Coronavirus disease - COVID-19;>>Proteoglycans in cancer;>>Bladder cancer
      • Gene Name：
      • HBEGF DTR DTS HEGFL
      • Protein Name：
      • Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]
      • Human Gene Id：
      • 1839
      • Human Swiss Prot No：
      • Q99075
      • Mouse Swiss Prot No：
      • Q06186
      • Immunogen：
      • Synthesized peptide derived from human protein . at AA range: 130-210
      • Specificity：
      • HBEGF Polyclonal Antibody detects endogenous levels of protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500-2000 ELISA 1:5000-20000
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Observed Band(KD)：
      • 22kD
      • Background：
      • function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,
      • Function：
      • function:May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,PTM:O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937).,PTM:Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.,similarity:Contains 1 EGF-like domain.,subcellular location:Mature HB-EGF is released into the extracellular space and probably binds to a receptor.,
      • Subcellular Location：
      • [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
      • Expression：
      • Brain,Eye,Histiocytic lymphoma,Macrophage,
      • Products Images
      • Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night

      Attributes

      • Code：
      • YN2310
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-04-27
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