PPM1B Polyclonal Antibody

  • Catalog No.:YN2285
  • Applications:WB;ELISA
  • Reactivity:Human;Rat;Mouse
    • Target:
    • PPM1B
    • Fields:
    • >>MAPK signaling pathway
    • Gene Name:
    • PPM1B PP2CB
    • Protein Name:
    • Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
    • Human Gene Id:
    • 5495
    • Human Swiss Prot No:
    • O75688
    • Mouse Swiss Prot No:
    • P36993
    • Immunogen:
    • Synthesized peptide derived from human protein . at AA range: 310-390
    • Specificity:
    • PPM1B Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD):
    • 52kD
    • Background:
    • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008],
    • Function:
    • alternative products:Additional isoforms seem to exist,catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.,similarity:Belongs to the PP2C family.,subunit:Monomer.,tissue specificity:Highly expressed in heart and skeletal muscle.,
    • Subcellular Location:
    • Cytoplasm, cytosol . Membrane ; Lipid-anchor . Weakly associates at the membrane and N-myristoylation mediates the membrane localization. .
    • Expression:
    • Highly expressed in heart and skeletal muscle.