RASA2 Polyclonal Antibody
- Catalog No.:YN1855
- Applications:WB;ELISA
- Reactivity:Human;Mouse;Rat
- Target:
- RASA2
- Fields:
- >>MAPK signaling pathway;>>Ras signaling pathway;>>Viral carcinogenesis
- Gene Name:
- RASA2 GAP1M RASGAP
- Protein Name:
- Ras GTPase-activating protein 2 (GAP1m)
- Human Gene Id:
- 5922
- Human Swiss Prot No:
- Q15283
- Mouse Swiss Prot No:
- P58069
- Rat Swiss Prot No:
- Q63713
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Specificity:
- RASA2 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 93kD
- Background:
- The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
- Function:
- function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,
- Subcellular Location:
- Cytoplasm. Cytoplasm, perinuclear region.
- Expression:
- Blood,Brain,
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