• Target：
• I12R2

• Fields：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Pathways in cancer;>>Inflammatory bowel disease

• Gene Name：
• IL12RB2

• Protein Name：
• Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)

• Human Gene Id：
• 3595

• Human Swiss Prot No：
• Q99665

• Mouse Swiss Prot No：
• P97378

• Immunogen：
• Synthesized peptide derived from human protein . at AA range: 270-350

• Specificity：
• I12R2 Polyclonal Antibody detects endogenous levels of protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Observed Band(KD)：
• 94kD

• Background：
• interleukin 12 receptor subunit beta 2(IL12RB2) Homo sapiens The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012],

• Function：
• developmental stage:Maximum levels in Th1 cells between day 3 and day 8 of activation.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.,induction:In vitro, up-regulated by interferon alpha.,polymorphism:Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.,PTM:On IL12 binding, phosphorylated on C-terminal ty

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Isoform 2 is expressed at similar levels in both naive and activated T-cells.

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