• Target：
• COX2

• Fields：
• >>Arachidonic acid metabolism;>>Metabolic pathways;>>NF-kappa B signaling pathway;>>VEGF signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>Ovarian steroidogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Leishmaniasis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>MicroRNAs in cancer;>>Small cell lung cancer

• Gene Name：
• PTGS2 COX2

• Protein Name：
• Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

• Human Gene Id：
• 5743

• Human Swiss Prot No：
• P35354

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:100-1:500,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 69kD

• Observed Band(KD)：
• 75kD

• Background：
• Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],

• Function：
• catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,

• Subcellular Location：
• Cytoplasm

• Expression：
• Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe

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Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction. Frontiers in Molecular Biosciences Front Mol Biosci. 2021 Aug;0:793 IHC Rat 1:200 Islet tissue

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Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2α/COX-2. MEDICAL ONCOLOGY Med Oncol. 2015 Jan;32(1):1-9 WB Human 786-O cell

Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis Scientific Reports Hou Huimin WB Human 1:1000 Human umbilical vein endothelial cells (HUVEC)

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