Hsp90 (PT0053R) rabbit mAb
- Catalog No.:YM8026
- Applications:WB;IHC;IF;IP;ELISA
- Reactivity:Human; Mouse; Rat;
- Target:
- HSP90B
- Fields:
- >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
- Gene Name:
- HSP90AB1
- Protein Name:
- Heat shock protein HSP 90-beta
- Human Gene Id:
- 3326
- Human Swiss Prot No:
- P08238
- Mouse Gene Id:
- 15516
- Mouse Swiss Prot No:
- P11499
- Rat Gene Id:
- 301252
- Rat Swiss Prot No:
- P34058
- Specificity:
- endogenous
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Monoclonal, rabbit, IgG, Kappa
- Dilution:
- IHC 1:200-1000,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200
- Purification:
- Protein A
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84
- Molecular Weight(Da):
- 85kD
- Observed Band(KD):
- 85kD
- Background:
- This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],
- Function:
- function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,
- Subcellular Location:
- Cytoplasm, Nuclear
- Expression:
- Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon
Metabolites profiling and pharmacokinetics of troxipide and its pharmacodynamics in rats with gastric ulcer. Scientific Reports Sci Rep-Uk. 2020 Aug;10(1):1-21 IHC Rat Stomach
Correlation between nuclear expression of heat shock protein 90 in dermis and glucocorticoid resistance in bullous dermatosis STEROIDS Wenqing Wang IF Human epidermis
A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects JOURNAL OF NANOBIOTECHNOLOGY Shaojie Dong WB Mouse 1:2000 novel multifunctional sodium nitroprusside and Fe2+ ions loaded microneedles (SNP-Fe@MNs)
Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma Cancer Control Hai-Feng Wang WB Human 1:2000 KYSE150 cell
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- Antibody-FAQs
- Products Images
- Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-Hsp90 (PT0053R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: PC12 Lane 2: PANC-1 Lane 3: HepG2 Predicted band size: 85kDa Observed band size: 85kDa
- Human tonsil testis was stained with Anti-HSP90 (PT0053R) rabbit Antibody
- Mouse testis was stained with Anti-HSP90 (PT0053R) rabbit Antibody