MutS Protein Homolog 2(MSH2) (ABT21R) rabbit mAb
- Catalog No.：YM7268
- Applications：WB; IHC; ELISA
- Reactivity：Human;
- Target：
- MSH2
- Fields：
- >>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer
- Gene Name：
- MSH2
- Protein Name：
- MutS Protein Homolog 2(MSH2)
- Human Gene Id：
- 3662
- Human Swiss Prot No：
- P43246
- Immunogen：
- Synthesized peptide derived from human MutS Protein Homolog 2(MSH2) AA range:600-700
- Specificity：
- This antibody detects endogenous levels of MSH2
- Formulation：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source：
- Monoclonal, Rabbit IgG1, Kappa
- Dilution：
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- Purification：
- Recombinant Expression and Affinity purified
- Storage Stability：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name：
- DNA mismatch repair protein Msh2;MutS protein homolog 2;MSH2;hMSH2
- Molecular Weight(Da)：
- 105kD
- Function：
- disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal
- Subcellular Location：
- Nucleus . Chromosome .
- Expression：
- Ubiquitously expressed.
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- Antibody-FAQs
- Products Images
- Immunohistochemical analysis of paraffin-embedded human Colon adenocarcinomas with loss of PMS2 expression. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
- Immunohistochemical analysis of paraffin-embedded human Colon adenocarcinomas with normal PMS2 expression.4. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
- Immunohistochemical analysis of paraffin-embedded human Colon adenocarcinomas with normal PMS2 expression. 1, Antibody was incubated at 4° overnight. 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
