• Target：
• CD105(Endoglin)

• Gene Name：
• ENG

• Protein Name：
• CD105(Endoglin)

• Human Gene Id：
• 3662

• Human Swiss Prot No：
• P17813

• Immunogen：
• Synthesized peptide derived from human CD105 AA range:400-500

• Specificity：
• This antibody detects endogenous levels of CD105(Endoglin)

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AI528660;AI662476;CD 105;CD105;CD105 antigen;EGLN_HUMAN;END;Endoglin;Eng;FLJ41744;HHT1;ORW;ORW1;Osler Rendu Weber syndrome 1;RP11 228B15.2;S endoglin;S-endoglin;SN6

• Molecular Weight(Da)：
• 71kD

• Function：
• disease:Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.,function:Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.,subunit:Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).

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