• Target：
• ROS1

• Gene Name：
• ROS1 MCF3 ROS

• Protein Name：
• ROS1 (Tyr2274)

• Human Gene Id：
• 6098

• Human Swiss Prot No：
• P08922

• Mouse Gene Id：
• 19886

• Mouse Swiss Prot No：
• Q78DX7

• Rat Gene Id：
• 25346

• Rat Swiss Prot No：
• Q63132

• Immunogen：
• Synthesized phosho peptide around human ROS1. AA range:1400-1600

• Specificity：
• This antibody detects endogenous levels of ROS1

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 264kD

• Background：
• This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Expressed in brain. Expression is increased in primary gliomas.

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