Oct-2 (PT0120R) rabbit mAb

  • Catalog No.:YM7177
  • Applications:IHC;WB; ELISA
  • Reactivity:Human;Mouse;
    • Target:
    • Oct-2
    • Fields:
    • >>Herpes simplex virus 1 infection;>>Lipid and atherosclerosis
    • Gene Name:
    • POU2F2
    • Protein Name:
    • Oct-2
    • Human Gene Id:
    • 5452
    • Human Swiss Prot No:
    • P09086
    • Immunogen:
    • Synthesized peptide derived from human Oct-2 AA range:250-350
    • Specificity:
    • This antibody detects endogenous levels of Oct-2
    • Formulation:
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source:
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution:
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • Purification:
    • Recombinant Expression and Affinity purified
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • class 2;Lymphoid restricted immunoglobulin octamer binding protein;Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2;NF A2;Oct 2;Oct-2;Octamer binding transcription factor 2;Octamer-binding protein 2;Octamer-binding transcription factor 2;OTF-2;OTF2;PO2F2_HUMAN;POU domain;POU domain class 2 transcription factor 2;POU2F2;transcription factor 2
    • Molecular Weight(Da):
    • 51kD
    • Background:
    • The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
    • Function:
    • function:Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR and PGR.,tissue specificity:Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147.,
    • Subcellular Location:
    • Nuclear
    • Expression:
    • Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.