Neurofilament (PT0124R) rabbit mAb

  • Catalog No.：YM7175
  • Applications：IHC;WB; ELISA
  • Reactivity：Human;
    • Target：
    • NF-L
    • Fields：
    • >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
    • Gene Name：
    • NEFL
    • Protein Name：
    • Neurofilament
    • Human Gene Id：
    • 4747
    • Human Swiss Prot No：
    • P07196
    • Immunogen：
    • Synthesized peptide derived from human Neurofilament AA range:400-543
    • Specificity：
    • This antibody detects endogenous levels of NF-L
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • 150 kDa medium;160 kDa neurofilament protein;2 kDa neurofilament protein;200 kDa neurofilament protein;68 kDa neurofilament protein;AI847934;CMT1F;CMT2CC;CMT2E;FLJ53642;KIAA0845;light molecular weight neurofilament protein;Micro glutamic acid-rich protein;mKIAA0845;Nef3;NEFH;NEFL;NEFM;Neurofilament 3;Neurofilament heavy polypeptide 200 kDa;Neurofilament heavy polypeptide;Neurofilament light polypeptide 68 kDa;Neurofilament light polypeptide;Neurofilament medium polypeptide 150 kDa;Neurofilament medium polypeptide;Neurofilament protein heavy polypeptide;Neurofilament protein light chain;Neurofilament protein light polypeptide;Neurofilament protein medium polypeptide;neurofilament subunit NF-L;Neurofilament triplet H protein;Neurofilament triplet L protein;Neurofilament triplet M protein;neurofilament-3 (150 kD medium);NF-H;NF-L;NF-M;NF160;NF165;NF200;NF68;NFH;NFL;NFM;NFM_HUMAN;PPP1R110;protein phosphatase 1, regulatory subunit 110
    • Molecular Weight(Da)：
    • 62kD
    • Background：
    • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
    • Function：
    • caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac
    • Subcellular Location：
    • Cytoplasmic
    • Expression：
    • Cytoplasmic

    Attributes

    • Code：
    • YM7175
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-24
    Order

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