MyoD1 (ABT147R) rabbit mAb
- Catalog No.:YM7168
- Applications:WB; IHC; ELISA
- Reactivity:Human; (predicted: Mouse; Rat)
- Target:
- MyoD
- Fields:
- >>Spinocerebellar ataxia
- Gene Name:
- MYOD1;BHLHC1;MYF3;MYOD
- Protein Name:
- Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3)
- Human Gene Id:
- 4654
- Human Swiss Prot No:
- P15172
- Immunogen:
- Synthesized peptide derived from human MyoD1 AA range:100-200
- Specificity:
- This antibody detects endogenous levels of MyoD
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Monoclonal, Rabbit IgG1, Kappa
- Dilution:
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- Purification:
- Recombinant Expression and Affinity purified
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Myoblast determination protein 1;Class C basic helix-loop-helix protein 1 (bHLHc1);Myogenic factor 3 (Myf-3);MYOD1
- Molecular Weight(Da):
- 35kD
- Background:
- This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],
- Function:
- function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,
- Subcellular Location:
- Nucleus.
- Expression:
- Muscle,Skeletal muscle,
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