• Target：
• ICAM-1

• Fields：
• >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>Natural killer cell mediated cytotoxicity;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Staphylococcus aureus infection;>>Influenza A;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Rheumatoid arthritis;>>Viral myocarditis;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• Gene Name：
• ICAM1

• Protein Name：
• Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

• Human Gene Id：
• 3383

• Human Swiss Prot No：
• P05362

• Immunogen：
• Synthesized peptide derived from human CD54 AA range:100-200

• Specificity：
• This antibody detects endogenous levels of ICAM-1

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Antigen identified by monoclonal BB2;BB 2;BB2;CD 54;CD_antigen=CD54;CD54;Cell surface glycoprotein P3.58;Human rhinovirus receptor;ICAM 1;ICAM-1;ICAM1;ICAM1_HUMAN;intercellular adhesion molecule 1 (CD54);intercellular adhesion molecule 1 (CD54), human rhinovirus receptor;Intercellular adhesion molecule 1;Major group rhinovirus receptor;MALA 2;MALA2;MyD 10;MyD10;P3.58;Surface antigen of activated B cells;Surface antigen of activated B cells, BB2

• Molecular Weight(Da)：
• 58kD

• Background：
• This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],

• Function：
• function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell a

• Subcellular Location：
• Membranous

• Expression：
• Blood,Kidney,Liver,Melanoma,Plasma,

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