• Target：
• CD38

• Fields：
• >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Hematopoietic cell lineage;>>Oxytocin signaling pathway;>>Salivary secretion;>>Pancreatic secretion

• Gene Name：
• CD38

• Protein Name：
• ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)

• Human Gene Id：
• 952

• Human Swiss Prot No：
• P28907

• Immunogen：
• Synthesized peptide derived from human CD38 AA range:200-300

• Specificity：
• This antibody detects endogenous levels of CD38

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Acute lymphoblastic leukemia cells antigen CD38;ADP ribosyl cyclase 1;ADP ribosyl cyclase;ADP ribosyl cyclase/cyclic ADP-ribose hydrolase;ADP-ribosyl cyclase 1;ADPRC 1;ADPRC1;cADPr hydrolase 1;CD 38;CD38;CD38 antigen (p45);CD38 antigen;CD38 molecule;Cd38-rs1;CD38_HUMAN;CD38H;Cyclic ADP ribose hydrolase;Cyclic ADP ribose hydrolase 1;Cyclic ADP-ribose hydrolase 1;EC 3.2.2.5;Ecto nicotinamide adenine dinucleotide glycohydrolase;I-19;I19 (Mouse);Lymphocyte differentiation antigen CD38;NAD(+) nucleosidase;NIM-R5 antigen;NIMR5 antigen (Mouse);OTTHUMP00000158633;OTTHUMP00000217743;p45;T10

• Molecular Weight(Da)：
• 34kD

• Background：
• The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

• Function：
• catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,

• Subcellular Location：
• Membranous

• Expression：
• Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

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