• Target：
• CD35

• Fields：
• >>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Tuberculosis

• Gene Name：
• CR1

• Protein Name：
• Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

• Human Gene Id：
• 1378

• Human Swiss Prot No：
• P17927

• Immunogen：
• Synthesized peptide derived from human CD35 AA range:300-400

• Specificity：
• This antibody detects endogenous levels of CD35

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• C3 binding protein;C3b/C4b receptor;C3BR;C4BR;CD 35;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement component (3b/4b) receptor 1 including Knops blood group system;Complement component receptor 1;Complement receptor 1;Complement receptor type 1;CR 1;CR1;CR1_HUMAN;KN;Knops blood group antigen

• Molecular Weight(Da)：
• 224kD

• Background：
• This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants

• Function：
• function:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podo

• Subcellular Location：
• Membranous

• Expression：
• Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.

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