CD34 (ABT218R) rabbit mAb

  • Catalog No.：YM7049
  • Applications：IHC; ELISA
  • Reactivity：Human;
    • Target：
    • CD34
    • Fields：
    • >>Cell adhesion molecules;>>Hematopoietic cell lineage
    • Gene Name：
    • CD34
    • Protein Name：
    • Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)
    • Human Gene Id：
    • 947
    • Human Swiss Prot No：
    • P28906
    • Immunogen：
    • Synthesized peptide derived from human CD34 AA range:150-250
    • Specificity：
    • This antibody detects endogenous levels of CD34
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500, ELISA 1:5000-20000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Hematopoietic progenitor cell antigen CD34;CD34
    • Background：
    • The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
    • Function：
    • alternative products:Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,disease:Abnormal CD34 expression in leukemogenesis.,function:Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tiss
    • Subcellular Location：
    • Membrane; Single-pass type I membrane protein.
    • Expression：
    • Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

    Attributes

    • Code：
    • YM7049
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-12-24
    Order

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