CD14 (ABT194R) rabbit mAb

  • Catalog No.：YM7032
  • Applications：IHC; ELISA
  • Reactivity：Human;
    • Target：
    • CD14
    • Fields：
    • >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Phagosome;>>Toll-like receptor signaling pathway;>>Hematopoietic cell lineage;>>Alcoholic liver disease;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Amoebiasis;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Lipid and atherosclerosis
    • Gene Name：
    • CD14
    • Protein Name：
    • CD14
    • Human Gene Id：
    • 929
    • Human Swiss Prot No：
    • P08571
    • Immunogen：
    • Synthesized peptide derived from human CD14 AA range:1-100
    • Specificity：
    • This antibody detects endogenous levels of CD14
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500, ELISA 1:5000-20000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • CD 14;CD_antigen=CD14;CD14;CD14 antigen;CD14 molecule;CD14_HUMAN;LPS-R;Mo2;Monocyte differentiation antigen CD14;Monocyte differentiation antigen CD14 urinary form;Monocyte differentiation antigen CD14, membrane-bound form;Myeloid cell specific leucine rich glycoprotein;Myeloid cell-specific leucine-rich glycoprotein
    • Background：
    • The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010],
    • Function：
    • function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
    • Subcellular Location：
    • Membranous, Cytoplasmic
    • Expression：
    • Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

    Attributes

    • Code：
    • YM7032
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-03
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