• Target：
• Nucleophosmin

• Gene Name：
• NPM1 NPM

• Protein Name：
• Nucleophosmin

• Human Gene Id：
• 4869

• Human Swiss Prot No：
• P06748

• Immunogen：
• Synthesized peptide derived from human Nucleophosmin AA range: 100-200

• Specificity：
• The antibody can specifically recognize human Nucleophosmin protein.

• Formulation：
• The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300

• Source：
• Mouse, Monoclonal/IgG2b, kappa

• Dilution：
• Ready to use for IHC

• Purification：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• 2°C to 8°C/1 year

• Other Name：
• Nucleophosmin (NPM;Nucleolar phosphoprotein B23;Nucleolar protein NO38;Numatrin)

• Background：
• This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009],

• Function：
• disease:A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1.,disease:A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA.,disease:A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated.,disease:Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location.,function:Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressor

• Subcellular Location：
• Nuclear, Cytoplasmic

• Expression：
• Nuclear, Cytoplasmic

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