MUM1 (ABT080) Mouse mAb

    • Catalog No.:YM6893
    • Applications:IHC;WB;ELISA
    • Reactivity:Human;
      • Target:
      • MUM1
      • Fields:
      • >>Th17 cell differentiation
      • Gene Name:
      • IRF4 MUM1
      • Protein Name:
      • MUM1
      • Human Gene Id:
      • 3662
      • Human Swiss Prot No:
      • Q15306
      • Immunogen:
      • Synthesized peptide derived from human MUM1 AA range: 350-451
      • Specificity:
      • The antibody can specifically recognize human MUM1 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse, Monoclonal/IgG1, Kappa
      • Dilution:
      • IHC-p 1:200-400, WB 1:200-1000, ELISA 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Interferon regulatory factor 4 (IRF-4;Lymphocyte-specific interferon regulatory factor;LSIRF;Multiple myeloma oncogene 1;NF-EM5)
      • Molecular Weight(Da):
      • 52kD
      • Background:
      • The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
      • Function:
      • disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
      • Subcellular Location:
      • Nuclear
      • Expression:
      • Lymphoid cells.
      • Products Images
      • Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-MUM1(ABT080)antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: Daudi Predicted band size: 52kDa Observed band size: 52kDa
      • Human colon tissue was stained with Anti-MUM1 (ABT080) Antibody
      • Human diffuse large B-cell lymphoma tissue was stained with Anti-MUM1 (ABT080) Antibody
      • Human diffuse large B-cell lymphoma tissue was stained with Anti-MUM1 (ABT080) Antibody
      • Human tonsil tissue was stained with Anti-MUM1 (ABT080) Antibody
      • Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-MUM1 (ABT080)antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: Daudi Predicted band size: 52kDa Observed band size: 52kDa