NSE (PT2281) mouse mAb (Ready to Use)

    • Catalog No.:YM6755R
    • Applications:IHC
    • Reactivity:Human;Mouse;Rat;
      • Target:
      • Enolase
      • Fields:
      • >>Glycolysis / Gluconeogenesis;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>RNA degradation;>>HIF-1 signaling pathway
      • Gene Name:
      • ENO2
      • Protein Name:
      • Neuron-Specific Enolase(NSE)
      • Human Gene Id:
      • 2026
      • Human Swiss Prot No:
      • P09104
      • Immunogen:
      • Synthesized peptide derived from human Neuron-Specific Enolase(NSE) AA range: 300-434
      • Specificity:
      • The antibody can specifically recognize human NSE protein.
      • Formulation:
      • The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
      • Source:
      • Mouse, Monoclonal/IgG1, kappa
      • Dilution:
      • Ready to use for IHC
      • Purification:
      • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • 2°C to 8°C/1 year
      • Other Name:
      • Gamma-enolase (EC 4.2.1.11;2-phospho-D-glycerate hydro-lyase;Enolase 2;Neural enolase;Neuron-specific enolase;NSE)
      • Background:
      • enolase 2(ENO2) Homo sapiens This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008],
      • Function:
      • catalytic activity:2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.,cofactor:Magnesium. Required for catalysis and for stabilizing the dimer.,developmental stage:During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.,function:Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.,induction:Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jacob disease.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.,similarity:Belongs to the enolase family.,subcellular location:Can translocate to the plasma membrane
      • Subcellular Location:
      • Cytoplasmic
      • Expression:
      • The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
      • Products Images
      • Human colon tissue was stained with Anti-NSE (PT2281) Antibody
      • Human pancreas tissue was stained with Anti-NSE (PT2281) Antibody
      • Human pancreas tissue was stained with Anti-NSE (PT2281) Antibody