COX-2 (cyclooxygenase-2)(ABT-COX2) mouse mAb

    • Catalog No.:YM6677
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human
      • Gene Name:
      • PTGS2 COX2
      • Protein Name:
      • Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)
      • Human Gene Id:
      • 5743
      • Human Swiss Prot No:
      • P35354
      • Immunogen:
      • Synthesized peptide derived from human COX-2 (cyclooxygenase-2)
      • Specificity:
      • This antibody detects endogenous levels of human Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse IgG
      • Dilution:
      • IF(paraffin section) 1:50-200IHC-p 1:100-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • prostaglandin-endoperoxide synthase 2(PTGS2) Homo sapiens Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],
      • Function:
      • catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,
      • Subcellular Location:
      • Cytoplasmic
      • Expression:
      • Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Colon carcinoma. 1,COX-2 (cyclooxygenase-2) Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Colon carcinoma. 1,COX-2 (cyclooxygenase-2) Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Colon carcinoma. 1,COX-2 (cyclooxygenase-2) Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Colon carcinoma. 1,COX-2 (cyclooxygenase-2) Antibody was diluted at 1:200(4° overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Western blot analysis of COX-2 (cyclooxygenase-2)Antibody at 1:1000 dilution.