Actin, smooth muscle (SMA) (ABT-SMA) mouse mAb (Ready to Use)
- Catalog No.：YM6566R
- Applications：IHC
- Reactivity：Human;Mouse;Rat;
- Target：
- Actin, smooth muscle (SMA)
- Fields：
- >>Vascular smooth muscle contraction;>>Apelin signaling pathway;>>Relaxin signaling pathway
- Gene Name：
- Actin, smooth muscle
- Protein Name：
- Actin, smooth muscle
- Human Swiss Prot No：
- P62736/P63267
- Immunogen：
- Synthesized peptide derived from human Actin, smooth muscle (SMA) AA range: 1-100
- Specificity：
- The antibody can specifically recognize smooth muscle actin and shows no reaction with actin of skelatal muscle or cardiac muscle.
- Formulation：
- The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
- Source：
- Mouse, Monoclonal/IgG2a, kappa
- Dilution：
- Ready to use for IHC
- Purification：
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- Storage Stability：
- 2°C to 8°C/1 year
- Background：
- The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
- Function：
- disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actin
- Subcellular Location：
- Cytoplasmic
- Expression：
- Pituitary,Uterus,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- September 08-2020
- FLOW-CYTOMEYRT-PROTOCOL
- May 20-2022
- Cell-Based ELISA│解您多样本WB检测之困扰
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- Antibody-FAQs
- Products Images
- Human appendix tissue was stained with anti-SMA(ABT-SMA) antibody.
- Human cardiac muscle tissue was stained with anti-SMA(ABT-SMA) antibody.
- Human colon tissue was stained with anti-SMA(ABT-SMA) antibody.
- Human leiomyoma tissue was stained with anti-SMA(ABT-SMA) antibody.
- Human skeletal muscle tissue was stained with anti-SMA(ABT-SMA) antibody.
- Human smooth muscle tissue was stained with anti-SMA(ABT-SMA) antibody.
- Fluorescence multiplex immunohistochemical analysis of normal human appendix tissue (formalin-fixed paraffin-embedded section).The section was incubated in 3 rounds of staining; in the order of Actin .( Catalog no:YM6566 1/200 dilution), Beta-catenin .(Catalog no: YM6675 1/200 dilution), MUM1. (Catalog no:YM6762 1/200 dilution),each using a separate fluorescent tyramide signal amplification system : Treble-Fluorescence immunohistochemical mouse/rabbit kit Catalog NO: RS0035 (pH9.0)
