PSMD11 (PTR1354) mouse mAb
- Catalog No.:YM4769
- Applications:WB;IF;ELISA
- Reactivity:Human;Mouse;Rat;
- Target:
- PSMD11
- Fields:
- >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection
- Gene Name:
- PSMD11
- Protein Name:
- 26S proteasome non-ATPase regulatory subunit 11
- Human Gene Id:
- 5717
- Human Swiss Prot No:
- O00231
- Mouse Gene Id:
- 69077
- Mouse Swiss Prot No:
- Q8BG32
- Immunogen:
- Synthesized peptide derived from human protein.AA range:250-350
- Specificity:
- This antibody detects endogenous levels of PSMD11.
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Mouse, Monoclonal/IgG3, kappa
- Dilution:
- WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- Purification:
- Protein G
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- PSMD11;26S proteasome non-ATPase regulatory subunit 11;26S proteasome regulatory subunit RPN6;26S proteasome regulatory subunit S9;26S proteasome regulatory subunit p44.5
- Molecular Weight(Da):
- 47kD
- Observed Band(KD):
- 47kD
- Background:
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq,
- Function:
- function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit S9 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,
- Subcellular Location:
- 0
- Expression:
- Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
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- Antibody-FAQs
- Products Images
- Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-PSMD11 (PTR1354) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: MCF7 Lane 2: HepG2 Lane 3: LN18 Lane 4: U2OS