• Target：
• 14-3-3 ζ

• Fields：
• >>Cell cycle;>>Oocyte meiosis;>>PI3K-Akt signaling pathway;>>Hippo signaling pathway;>>Hepatitis C;>>Hepatitis B;>>Viral carcinogenesis

• Gene Name：
• YWHAZ

• Protein Name：
• 14-3-3 protein zeta/delta

• Human Gene Id：
• 7534

• Human Swiss Prot No：
• P63104

• Mouse Gene Id：
• 22631

• Mouse Swiss Prot No：
• P63101

• Rat Gene Id：
• 25578

• Rat Swiss Prot No：
• P63102

• Immunogen：
• Synthesized peptide derived from human protein. AA range:1-100

• Specificity：
• This antibody detects endogenous levels of 14-3-3 ζ  protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal,Mouse,IgG1,kappa

• Dilution：
• WB 1:500-2000.IF 1:100-500.ELISA 1:1000-5000.

• Purification：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• YWHAZ;14-3-3 protein zeta;Protein kinase C inhibitor protein 1;KCIP-1

• Molecular Weight(Da)：
• 28kD

• Observed Band(KD)：
• 28kD

• Background：
• This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008],

• Function：
• caution:Was originally (PubMed:1577711) thought to have phospholipase A2 activity.,function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.,similarity:Belongs to the 14-3-3 family.,subcellular location:Located to

• Subcellular Location：
• Cytoplasmic

• Expression：
• B-cell lymphoma,Bone marrow

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