Galectin-9 (PTR1201) mouse mAb
- Catalog No.:YM4735
- Applications:WB;IF;ELISA
- Reactivity:Human;
- Target:
- Galectin-9
- Gene Name:
- LGALS9
- Protein Name:
- Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
- Human Gene Id:
- 3965
- Human Swiss Prot No:
- O00182
- Mouse Gene Id:
- 16859
- Mouse Swiss Prot No:
- O08573
- Immunogen:
- Synthesized peptide derived from human Galectin-9 AA range: 1-100
- Specificity:
- This antibody detects endogenous levels of Galectin-9 protein.
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Mouse, Monoclonal/IgG
- Dilution:
- WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- Purification:
- Protein G
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 39kD
- Observed Band(KD):
- 37kD
- Background:
- galectin 9(LGALS9) Homo sapiens The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],
- Function:
- Binds galactosides . Has high affinity for the Forssman pentasaccharide . Ligand for HAVCR2/TIM3 . Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death . Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration . Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation . Expands regulatory T-c
- Subcellular Location:
- 0
- Expression:
- Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).
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- Antibody-FAQs
- Products Images
- Whole cell lysates were separated by 12% SDS-PAGE, and the membrane was blotted with anti-Galectin-9 (PTR1201) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: THP-1