• Target：
• Claudin-2

• Fields：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• Gene Name：
• CLDN2 PSEC0059 SP82 UNQ705/PRO1356

• Protein Name：
• Claudin 2

• Human Gene Id：
• 9075

• Human Swiss Prot No：
• P57739

• Immunogen：
• Synthesized peptide derived from human Claudin 2 AA range: 150-230

• Specificity：
• This antibody detects endogenous levels of Claudin 2 protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG2b, kappa

• Dilution：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• Purification：
• Protein G

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Claudin-2 (SP82)

• Molecular Weight(Da)：
• 25kD

• Observed Band(KD)：
• 50kD

• Background：
• This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],

• Function：
• function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

• Subcellular Location：
• Membranous

• Expression：
• Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,

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