• Target：
• Lamin B1

• Fields：
• >>Apoptosis

• Gene Name：
• LMNB1

• Protein Name：
• Lamin-B1

• Human Gene Id：
• 4001

• Human Swiss Prot No：
• P20700

• Mouse Gene Id：
• 16906

• Mouse Swiss Prot No：
• P14733

• Rat Gene Id：
• 116685

• Rat Swiss Prot No：
• P70615

• Immunogen：
• Recombinant Protein of Lamin-B1

• Specificity：
• The antibody detects endogenous Lamin B1 protein.

• Formulation：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:2000-5000 IP:1:200 IF 1:200 IHC 1:50-300

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LMNB1;LMN2;LMNB;Lamin-B1

• Observed Band(KD)：
• 68kD

• Background：
• lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

• Function：
• disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle

• Subcellular Location：
• Nucleus lamina .

• Expression：
• Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,

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Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2019 Aug 06 WB Human Beas-2Bcell, NSCLC cell

Boost therapy of hepatocellular carcinoma by amplifying vicious cycle between mitochondrial oxidative stress and endoplasmic reticulum stress via biodegradable ultrasmall nanoparticles and old drug Nano Today Hao Zhang WB Human

Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway. JOURNAL OF ETHNOPHARMACOLOGY Junning Zhao WB Mouse 1:5000 brains

Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma ENDOCRINE-RELATED CANCER Yihao Chen WB,IHC Human 1:1000 Adrenocortical carcinoma (ACC) tissue,adrenal adenoma tissue SW13 cell,H295R cell

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