EIF4EBP3 mouse mAb

    • Catalog No.：YM1455
    • Applications：WB
    • Reactivity：Transfected
      • Target：
      • EIF4EBP3
      • Gene Name：
      • eif4ebp3
      • Human Gene Id：
      • 8637
      • Human Swiss Prot No：
      • O60516
      • Mouse Swiss Prot No：
      • Q80VV3
      • Immunogen：
      • Recombinant protein of human EIF4EBP3.
      • Specificity：
      • Transfected Only.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • wb dilution 1:1000
      • Purification：
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • 4E BP3;4E-BP3;4EBP3;eIF4E binding protein 3;Eukaryotic initiation factor 4E binding protein 3;Eukaryotic translation initiation factor 4E binding protein 3;OTTHUMP00000159879.
      • Observed Band(KD)：
      • 11kD
      • Background：
      • eukaryotic translation initiation factor 4E binding protein 3(EIF4EBP3) Homo sapiens This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010],
      • Function：
      • function:May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.,function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex.,PTM:Phosphorylated.,similarity:Belongs to the eIF4E-binding protein family.,similarity:Belongs to the mask family.,similarity:Contains 1 KH domain.,similarity:Contains 25 ANK repeats.,subunit:EIF4EBP3 interacts with EIF4E.,subunit:Interacts with PTPN11. Isoform 2 interacts with VPR.,tissue specificity:Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.,tissue specificity:Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expr
      • Subcellular Location：
      • cytoplasm,membrane,eukaryotic translation initiation factor 4F complex,
      • Expression：
      • Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
      • Products Images
      • Western blot detection of EIF4EBP3 in CHO-K1 cell lysate(B)and CHO-K1 transfected by EGFP-EIF4EBP3 fragment(A)cell lysate using EIF4EBP3 mouse mAb (1:1000 diluted).

      Attributes

      • Code：
      • YM1455
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 160 / 280 / 450
      • Delivery：
      • 2024-07-25
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