• Target：
• SWAP70

• Gene Name：
• swap70

• Human Gene Id：
• 23075

• Human Swiss Prot No：
• Q9UH65

• Mouse Swiss Prot No：
• Q6A028

• Immunogen：
• Purified recombinant human SWAP70 protein fragments expressed in E.coli.

• Specificity：
• This antibody detects endogenous levels of SWAP70 and does not cross-react with related proteins.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb 1:1000

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KIAA0640;70kDa;AV235546;FLJ39540;HSPC321;SWA 70 protein;SWAP 70;SWAP switching B-cell complex 70kDa subunit;SWAP-70;SWAP70;Switch associated protein 70;Switch-associated protein 70;SWP70_HUMAN.

• Observed Band(KD)：
• 70kD

• Background：
• domain:The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.,function:Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.,PTM:Tyrosine-phosphorylated.,similarity:Contains 1 PH domain.,subcellular location:In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.,subunit:The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.,tissue specificity:Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).,

• Function：
• domain:The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.,function:Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.,PTM:Tyrosine-phosphorylated.,similarity:Contains 1 PH domain.,subcellular location:In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extendi

• Subcellular Location：
• Cytoplasm . Cell membrane. Nucleus . Cell projection, lamellipodium . Cytoplasm, cytoskeleton . In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). .

• Expression：
• Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).

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