Mannose Phosphate Isomerase mouse mAb

    • Catalog No.：YM1237
    • Applications：WB;ICC
    • Reactivity：Human;Rat
      • Target：
      • Mannose Phosphate Isomerase
      • Fields：
      • >>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Biosynthesis of nucleotide sugars
      • Gene Name：
      • mpi
      • Human Gene Id：
      • 4351
      • Human Swiss Prot No：
      • P34949
      • Mouse Swiss Prot No：
      • Q924M7
      • Immunogen：
      • Purified recombinant human Mannose Phosphate Isomerase protein fragments expressed in E.coli.
      • Specificity：
      • This antibody detects endogenous levels of Mannose Phosphate Isomerase and does not cross-react with related proteins.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • wb 1:1000 icc 1:300
      • Purification：
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • PMI1;CDG1B;FLJ39201;Mannose 6 phosphate isomerase;Mannose-6-phosphate isomerase;MANNOSEPHOSPHATE ISOMERASE;MGC94106;MPI;MPI_HUMAN;Phosphohexomutase;phosphomannose isomerase 1;Phosphomannose isomerase;PMI;PMI1.
      • Observed Band(KD)：
      • 54kD
      • Background：
      • Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
      • Function：
      • catalytic activity:D-mannose 6-phosphate = D-fructose 6-phosphate.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy.,function:Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.,pathway:Nucleotide-sugar biosynthesis; GDP-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.,similarity:Belongs to the mannose-6-phosp
      • Subcellular Location：
      • Cytoplasm .
      • Expression：
      • Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
      • Products Images
      • Western blot detection of Mannose Phosphate Isomerase in Rat kidney,Rat brain,A549 and Lncap cell lysates and using Mannose Phosphate Isomerase mouse mAb (1:1000 diluted).Predicted band size: 54KDa.Observed band size: 45KDa.
      • Immunocytochemistry stain of Hela using Mannose Phosphate Isomerase mouse mAb (1:300).

      Attributes

      • Code：
      • YM1237
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 160 / 280 / 450
      • Delivery：
      • 2024-12-01
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