• Target：
• PRMT1

• Fields：
• >>FoxO signaling pathway;>>Glucagon signaling pathway

• Gene Name：
• PRMT1

• Protein Name：
• Protein arginine N-methyltransferase 1

• Human Gene Id：
• 3276

• Human Swiss Prot No：
• Q99873

• Mouse Gene Id：
• 15469

• Mouse Swiss Prot No：
• Q9JIF0

• Rat Gene Id：
• 60421

• Rat Swiss Prot No：
• Q63009

• Immunogen：
• Purified recombinant human PRMT1 protein fragments expressed in E.coli.

• Specificity：
• PRMT1 Monoclonal Antibody detects endogenous levels of PRMT1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:1000 - 1:2000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PRMT1;HMT2;HRMT1L2;IR1B4;Protein arginine N-methyltransferase 1;Histone-arginine N-methyltransferase PRMT1;Interferon receptor 1-bound protein 4

• Molecular Weight(Da)：
• 42kD

• Background：
• This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011],

• Function：
• enzyme regulation:By BTG1, BTG2 and ILF3.,function:Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H and EWS.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP.,

• Subcellular Location：
• Nucleus . Nucleus, nucleoplasm . Cytoplasm . Cytoplasm, cytosol . Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). .

• Expression：
• Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).

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