Actinin-α2 Monoclonal Antibody

    • Catalog No.：YM1004
    • Applications：WB;IF
    • Reactivity：Human;Rat;Bovine;Chicken;Dog;Pig;Zebrafish
      • Target：
      • Actinin-α2
      • Fields：
      • >>Arrhythmogenic right ventricular cardiomyopathy
      • Gene Name：
      • ACTN2/ACTN3
      • Protein Name：
      • Alpha-actinin-2
      • Human Gene Id：
      • 88
      • Human Swiss Prot No：
      • P35609
      • Mouse Swiss Prot No：
      • Q9JI91
      • Immunogen：
      • Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.
      • Specificity：
      • Actinin-α2 Monoclonal Antibody detects endogenous levels of Actinin-α2 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • ACTN2;Alpha-actinin-2;Alpha-actinin skeletal muscle isoform 2;F-actin cross-linking protein
      • Molecular Weight(Da)：
      • 104kD
      • Background：
      • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],
      • Function：
      • disease:Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.,similarity:Belongs to the alpha-actinin family.,similarity:Contains 1 actin-binding domain.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 2 EF-hand domains.,similarity:Contains 4 spectrin repeats.,subcellular location:Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.,subunit:Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal r
      • Subcellular Location：
      • Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
      • Expression：
      • Expressed in both skeletal and cardiac muscle.
      • Products Images
      • Western Blot analysis using Actinin-α2 Monoclonal Antibody against HepG2 cell lysate.
      • Immunofluorescence analysis of HeLa cells using Actinin-α2 Monoclonal Antibody.

      Attributes

      • Code：
      • YM1004
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
      Order

      Related Products