WDR5 Monoclonal Antibody
- Catalog No.：YM0647
- Applications：WB;ELISA
- Reactivity：Human
- Target：
- WDR5
- Fields：
- >>Cushing syndrome
- Gene Name：
- WDR5
- Protein Name：
- WD repeat-containing protein 5
- Human Gene Id：
- 11091
- Human Swiss Prot No：
- P61964
- Mouse Swiss Prot No：
- P61965
- Immunogen：
- Purified recombinant fragment of human WDR5 expressed in E. Coli.
- Specificity：
- WDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein.
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Monoclonal, Mouse
- Dilution：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- Purification：
- Affinity purification
- Storage Stability：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name：
- WDR5;BIG3;WD repeat-containing protein 5;BMP2-induced 3-kb gene protein
- Molecular Weight(Da)：
- 37kD
- References：
- 1. Mol Syst Biol. 2007;3:89.
2. J Biol Chem. 2008 Nov 21;283(47):32162-75.
- Background：
- This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
- Function：
- function:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5.,
- Subcellular Location：
- Nucleus .
- Expression：
- Epithelium,Lung,Spleen,Uterus,
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- Antibody-FAQs
- Products Images
- Western Blot analysis using WDR5 Monoclonal Antibody against HeLa (1) cell lysate.
