• Target：
• TCP-1 β

• Gene Name：
• CCT2

• Protein Name：
• T-complex protein 1 subunit beta

• Human Gene Id：
• 10576

• Human Swiss Prot No：
• P78371

• Mouse Gene Id：
• 12461

• Mouse Swiss Prot No：
• P80314

• Rat Gene Id：
• 299809

• Rat Swiss Prot No：
• Q5XIM9

• Immunogen：
• Purified recombinant fragment of human TCP-1 β expressed in E. Coli.

• Specificity：
• TCP-1 β Monoclonal Antibody detects endogenous levels of TCP-1 β protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CCT2;99D8.1;CCTB;T-complex protein 1 subunit beta;TCP-1-beta;CCT-beta

• Molecular Weight(Da)：
• 57kD

• References：
• 1. J Biol Chem. 2009 May 29;284(22):14939-48.
  2. Mol Cell Proteomics. 2009 Jan;8(1):157-71.

• Background：
• The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],

• Function：
• function:Molecular chaperone; assist the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• B-cell lymphoma,Brain,Cajal-Retzius cell,Fetal brain cortex,Liver,P

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