TBX5 Monoclonal Antibody

    • Catalog No.：YM0611
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • TBX5
      • Gene Name：
      • TBX5
      • Protein Name：
      • T-box transcription factor TBX5
      • Human Gene Id：
      • 6910
      • Human Swiss Prot No：
      • Q99593
      • Mouse Swiss Prot No：
      • P70326
      • Immunogen：
      • Purified recombinant fragment of TBX5 expressed in E. Coli.
      • Specificity：
      • TBX5 Monoclonal Antibody detects endogenous levels of TBX5 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • TBX5;T-box transcription factor TBX5;T-box protein 5
      • Molecular Weight(Da)：
      • 58kD
      • References：
      • 1. Physiol Genomics. 2004 Jul 8;18(2):129-40.
        2. J Mol Cell Cardiol. 2003 Oct;35(10):1191-5.
      • Background：
      • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
      • Function：
      • disease:Defects in TBX5 are the cause of Holt-Oram syndrome (HOS) [MIM:142900]. HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects.,function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,
      • Subcellular Location：
      • Nucleus . Cytoplasm . Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. .
      • Expression：
      • Lung,Spleen,
      • Products Images
      • Western Blot analysis using TBX5 Monoclonal Antibody against HepG2 cell lysate (1).

      Attributes

      • Code：
      • YM0611
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-07-11
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